The comparison of acute myocardial infarction serum anticardiolipin antibody with healthy subjects, in Gorgan (Northern Iran).

Arthrosclerosis considered one of the most important causes of morbidity and mortality in industrial and developing countries. The rate of myocardial infarction in some countries is about 2 million annually with 1/4 of them is leading to death. This study was a case-control research, which was carried out as cross-sectional project in two groups, healthy and case subjects. The mean age and standard deviation of patients and control groups were nearly equal (55 +/- 10). The ELISA technique was applied to measure the serum antibody level. The sample populations in each group were exactly the same (120 person in each group). The gender distribution in case and control group was 44 female, 76 male and 45 female and 75 male, respectively. The Mean +/- SD of IgM in case group and control groups were 3.10 +/- 2.54 and 1.54 +/- 1.00, respectively. The Mean +/- SD for IgG in case and control groups were 5.90 +/- 3.84 and 3.08 +/- 1.95, respectively. The differences, between the mean of IgM and IgG in two groups of cases and control statistically were significant (p = 0.0001). In case group the Mean +/- SD for IgM for men and woman were 2.98 +/- 1.97 and 3.17 +/- 2.83, respectively, which this differences statistically, were not significant. In case group the Mean +/- SD for IgG were 5.14 +/- 3.45 and 6.35. The above findings indicated that the average of both IgG and IgM are higher among men compared to women. Due to high prevalence of acute coronary syndrome in Iran, the determination of anticardiolipin antibody (IgG) are applied for suspected acute coronary syndrome patients and further prevention measure should be taken for patient with higher serum anticardiolipin antibody.